![]() Visual hallucinations and insomnia complaints were highly genetically correlated (rg = 0.36, p = 6.4 × 10 -5). We found that auditory hallucinations were significantly genetically correlated with insomnia complaints (rg = -0.27, p = 1.1 × 10 -3), sleep duration (rg = 0.21, p = 9.7 × 10 -3), and ease of getting up (rg = 0.31, p = 2 × 10 -4). Mendelian randomization (MR) was conducted on trait pairs with significant genetic associations. Linkage disequilibrium score regression (LDSC) was used to investigate genetic correlations. GWAS results were obtained for positive PEs (N = 116,787-117,794) and sleep-related traits. The aim of the present study was to detect the genetic correlations and causal relationship between sleep-related traits and PEs using the largest current genome-wide association study (GWAS) summary statistics. Electronic address: studies have found that sleep problems are associated with psychotic experiences (PEs) across clinical designs, but many confounding factors from uncertain variables have been unclear in observational designs. Electronic address: 5 Department of Psychiatry, Laboratory of Neurological Diseases & Brain Function, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China Mental Health Research Center, Zigong Mental Health Center, Zigong, Sichuan Province, China Mental Health Research Center, Zigong Institute of Brain Science, Zigong, Sichuan Province, China Central Nervous System Drug Key Laboratory of Sichuan Province, Luzhou, Sichuan Province, China. 4 Mental Health Research Center, Zigong Mental Health Center, Zigong, Sichuan Province, China Mental Health Research Center, Zigong Institute of Brain Science, Zigong, Sichuan Province, China.Electronic address: 1 Medical Laboratory Center, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China. 3 Central Nervous System Drug Key Laboratory of Sichuan Province, Luzhou, Sichuan Province, China School of Pharmacy, Southwest Medical University, Luzhou, Sichuan Province, China.2 Department of Psychiatry, Laboratory of Neurological Diseases & Brain Function, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.1 Medical Laboratory Center, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.
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